{"id":439,"date":"2023-12-25T10:22:33","date_gmt":"2023-12-25T03:22:33","guid":{"rendered":"https:\/\/stemcellinnovation.com.vn\/2023\/?page_id=439"},"modified":"2024-12-08T10:22:07","modified_gmt":"2024-12-08T03:22:07","slug":"top-10-y-tuong-sci8","status":"publish","type":"page","link":"https:\/\/stemcellinnovation.com.vn\/2023\/top-10-y-tuong-sci8\/","title":{"rendered":"Top 10 \u00dd t\u01b0\u1edfng SCI#8"},"content":{"rendered":"\n
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T\u00ean \u0111\u1ed9i thi:<\/strong> 3 Con nh\u00e1i<\/p>\n\n\n\n

T\u00ean \u00fd t\u01b0\u1edfng:<\/strong> Lactose intolerance treatment via genetically engineered bacteria.<\/p>\n\n\n\n

Gi\u1edbi thi\u1ec7u:<\/strong> Lactose intolerance has a high prevalence worldwide, ranging between 57% and 65%. It is caused by a reduction or loss of the activity of the intestinal enzyme lactase\u2212phlorizin hydrolase, responsible for the digestion of lactose. This alteration determines an increased osmotic load in the small intestine and the fermentation of lactose by the bacterial flora, which leads to a high production of short-chain fatty acids and gas. This is followed by the onset of abdominal pain, diarrhea, and flatulence, increased risk of developing various extra-intestinal diseases, including cancers. Common treatments for the disease include dairy food avoidance, enzyme supplement prior to dairy food consumption or lactose-reduced food alternatives. Thus, currently, there\u2019s no permanent treatment for the disease.<\/p>\n\n\n\n

M\u1ee5c ti\u00eau\/Ph\u01b0\u01a1ng ph\u00e1p:<\/strong> The research aims to provide a permanent treatment option for the disease through the introduction of genetically engineered bacteria that can colonize the human intestine and actively produce human lactase.<\/p>\n<\/div>\n\n\n\n

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PH\u00c1T TRI\u1ec2N TH\u1ef0C PH\u1ea8M CH\u1ee8C N\u0102NG CH\u1ee8A EXOSOME H\u1ed6 TR\u1ee2 PH\u1ee4C H\u1ed2I T\u00ccNH TR\u1ea0NG SAU \u0110\u1ed8T QU\u1ef4<\/strong><\/p>\n\n\n\n

Abstract<\/strong>
\u0110\u1ed9t qu\u1ef5 l\u00e0 nguy\u00ean nh\u00e2n h\u00e0ng \u0111\u1ea7u g\u00e2y t\u00e0n t\u1eadt tr\u00ean to\u00e0n th\u1ebf gi\u1edbi v\u00e0 l\u00e0 nguy\u00ean nh\u00e2n g\u00e2y t\u1eed vong th\u1ee9 hai tr\u00ean th\u1ebf gi\u1edbi. H\u00e0ng n\u0103m, tr\u00ean th\u1ebf gi\u1edbi c\u00f3 15 tri\u1ec7u ng\u01b0\u1eddi b\u1ecb \u0111\u1ed9t qu\u1ef5 t\u1ea1o g\u00e1nh n\u1eb7ng v\u00e0 n\u1ed7i \u00e2u lo trong c\u1ed9ng \u0111\u1ed3ng. Th\u00f4ng th\u01b0\u1eddng c\u00f3 hai nguy\u00ean nh\u00e2n d\u1eabn t\u1edbi \u0111\u1ed9t qu\u1ef5 do t\u1eafc ngh\u1ebdn m\u1ea1ch m\u00e1u ho\u1eb7c do v\u1ee1 m\u1ea1ch m\u00e1u. D\u1eabn t\u1edbi gi\u00e1n \u0111o\u1ea1n qu\u00e1 tr\u00ecnh t\u01b0\u1edbi m\u00e1u l\u00ean n\u00e3o v\u00e0 g\u00e2y t\u1ed5n th\u01b0\u01a1ng n\u00e3o. Hi\u1ec7n t\u1ea1i, v\u1eabn ch\u01b0a c\u00f3 chi\u1ebfn l\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb hi\u1ec7u qu\u1ea3 n\u00e0o \u0111\u1ec3 th\u00fac \u0111\u1ea9y ph\u1ee5c h\u1ed3i th\u1ea7n kinh trong l\u00e2m s\u00e0ng tr\u1eeb ph\u1ee5c h\u1ed3i ch\u1ee9c n\u0103ng. Ph\u1ea7n l\u1edbn c\u00e1c thu\u1ed1c b\u1ea3o v\u1ec7 th\u1ea7n kinh c\u00f3 hi\u1ec7u qu\u1ea3 k\u00e9m khi kh\u00f4ng th\u1ec3 \u0111i qua h\u00e0ng r\u00e0o m\u00e1u n\u00e3o. V\u00ec v\u1eady, nh\u1eafm \u0111\u01b0a ra gi\u1ea3i ph\u00e1p hi\u1ec7u qu\u1ea3 \u0111\u1ed1i v\u1edbi t\u00ecnh tr\u1ea1ng \u0111\u1ed9t qu\u1ef5, v\u1edbi c\u00e1c nghi\u00ean c\u1ee9u ch\u1ee9ng minh t\u00e1c \u0111\u1ed9ng c\u1ee7a miRNA-124 v\u00e0 miRNA-126 l\u00ean qu\u00e1 h\u00ecnh h\u00ecnh th\u00e0nh m\u1ea1ch m\u00e1u m\u1edbi v\u00e0 th\u00fac \u0111\u1ea9y t\u0103ng sinh m\u1edbi t\u1ebf b\u00e0o th\u1ea7n kinh v\u00e0 ph\u00e2n t\u1eed nh\u1eafm tr\u00fang \u0111\u00edch t\u1ebf b\u00e0o th\u1ea7n kinh, LAMP. Nh\u00f3m k\u1ef3 v\u1ecdng exosome c\u00f3 kh\u1ea3 n\u0103ng mang c\u00e1c miRNA c\u00f3 t\u00e1c \u0111\u1ed9ng sinh h\u1ecdc n\u00e0y v\u00e0 bi\u1ec3u hi\u1ec7n ph\u00e2n t\u1eed LAMP. B\u00ean c\u1ea1nh \u0111\u00f3, h\u01b0\u1edbng t\u1edbi t\u00ednh ph\u1ed5 bi\u1ec3n s\u1ea3n ph\u1ea9m v\u00e0 d\u1ec5 d\u00e0ng s\u1eed d\u1ee5ng, nh\u00f3m s\u1eed d\u1ee5ng vi\u00ean nang \u0111\u1ec3 l\u01b0u gi\u1eef v\u00e0 b\u1ea3o qu\u1ea3n exosome. Th\u00f4ng qua \u0111\u00f3ng g\u00f3i v\u00e0o polypeptide hydrogel, exosome c\u00f3 kh\u1ea3 n\u0103ng ch\u1ed1ng ch\u1ecdi v\u1edbi c\u00e1c \u0111i\u1ec1u ki\u1ec7n c\u1ef1c \u0111o\u1ea1n v\u00e0 t\u0103ng kh\u1ea3 n\u0103ng h\u1ea5p th\u1ee5 t\u0103ng kh\u1ea3 n\u0103ng di chuy\u1ec3n qua ru\u1ed9t. V\u00ec v\u1eady, m\u1ee5c ti\u00eau c\u1ee7a \u0111\u1ed9i thi C double H l\u00e0 \u201cPh\u00e1t tri\u1ec3n s\u1ea3n ph\u1ea9m th\u1ee9c n\u0103ng h\u1ed7 tr\u1ee3 ph\u1ee5c h\u1ed3i t\u00ecnh tr\u1ea1ng sau \u0111\u1ed9t qu\u1ef5\u201d.<\/p>\n<\/div>\n\n\n\n

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B\u1ea3n t\u00f3m t\u1eaft poster c\u1ee7a nh\u00f3m H\u1ebft C\u1ee9u<\/strong><\/p>\n\n\n\n

Qu\u00e1ng g\u00e0 l\u00e0 m\u1ed9t b\u1ec7nh \u0111\u1eb7c h\u1eefu n\u1ed5i ti\u1ebfng \u1edf c\u00e1c n\u01b0\u1edbc nhi\u1ec7t \u0111\u1edbi n\u00f3i chung v\u00e0 Vi\u1ec7t Nam n\u00f3i ri\u00eang. C\u00e1c b\u1ec7nh nh\u00e2n qu\u00e1ng g\u00e0 ph\u1ea3i \u0111\u1ed1i m\u1eb7t v\u1edbi nguy c\u01a1 m\u00f9 m\u00e0u v\u00e0 m\u00f9 lo\u00e0 trong cu\u1ed9c \u0111\u1eddi do c\u00e1i ch\u1ebft mang t\u00ednh ti\u1ebfn tri\u1ec3n c\u1ee7a c\u00e1c t\u1ebf b\u00e0o \u1edf m\u00f4 m\u1eaft sau. Nghi\u00ean c\u1ee9u n\u00e0y c\u00f3 m\u1ee5c ti\u00eau t\u00ecm ra bi\u1ec7n ph\u00e1p ph\u00f2ng tr\u00e1nh bi\u1ebfn ch\u1ee9ng m\u00f9 \u1edf ng\u01b0\u1eddi b\u1ec7nh. S\u1eed d\u1ee5ng k\u00ednh \u00e1p tr\u00f2ng \u0111\u1ec3 t\u0103ng n\u1ed3ng \u0111\u1ed9 v\u00e0 th\u1eddi gian c\u01b0 tr\u00fa tr\u01b0\u1edbc m\u00e0ng gi\u00e1c m\u1ea1c c\u1ee7a thu\u1ed1c, nh\u00f3m hy v\u1ecdng t\u0103ng t\u00ednh th\u1ea5m v\u00e0 d\u00f2ng thu\u1ed1c \u0111\u1ebfn m\u00f4 \u0111\u00edch l\u00e0 b\u1ec1 m\u1eb7t v\u00f5ng m\u1ea1c kh\u00e1 kh\u00f3 ti\u1ebfp c\u1eadn. Nh\u00f3m c\u00f2n s\u1eed d\u1ee5ng thu\u1ed1c ph\u00e2n t\u1eed lo\u1ea1i nh\u1ecf l\u00e0 exosome ngu\u1ed3n g\u1ed1c t\u1ebf b\u00e0o g\u1ed1c, \u00edt g\u00e2y \u0111\u1ed9c, th\u00e2n thi\u1ec7n v\u1edbi ng\u01b0\u1eddi s\u1eed d\u1ee5ng. Ph\u00e1t tri\u1ec3n d\u1ef1a tr\u00ean c\u00e1c quy tr\u00ecnh \u0111\u00e3 c\u00f3 trong li\u1ec7u ph\u00e1p exosome v\u1edbi m\u00f4 h\u00ecnh 3D t\u1ebf b\u00e0o ph\u1ed5i v\u00e0 t\u1ebf b\u00e0o g\u1ed1c trung m\u00f4 m\u1ee1 \u0111\u00e3 \u0111i\u1ec1u tr\u1ecb th\u00e0nh c\u00f4ng m\u1ed9t s\u1ed1 b\u1ec7nh v\u00e0 do stress oxy ho\u00e1 (nh\u1edd kh\u1ea3 n\u0103ng v\u1eadn chuy\u1ec3n c\u00e1c t\u00edn hi\u1ec7u l\u00e0m t\u0103ng ho\u1ea1t \u0111\u1ed9ng c\u00e1c con \u0111\u01b0\u1eddng ch\u1ed1ng ROS c\u00f3 s\u1eb5n) v\u00e0 th\u00e0nh t\u1ef1u ph\u00e2n l\u1eadp bi\u1ec7t ho\u00e1 t\u1ebf b\u00e0o g\u1ed1c t\u1ebf b\u00e0o c\u1ea3m quang ng\u01b0\u1eddi \u0111\u00e3 th\u00e0nh c\u00f4ng t\u1eeb t\u1ebf b\u00e0o g\u1ed1c ph\u00f4i, nh\u00f3m mong mu\u1ed1n thu \u0111\u01b0\u1ee3c exosome t\u1eeb t\u1ebf b\u00e0o g\u1ed1c t\u1ebf b\u00e0o c\u1ea3m quang nu\u00f4i c\u1ea5y c\u00f3 t\u00e1c d\u1ee5ng \u0111\u1ea3o ng\u01b0\u1ee3c t\u00ecnh tr\u1ea1ng stress oxy ho\u00e1 \u1edf t\u1ebf b\u00e0o nh\u1eadn – t\u1ebf b\u00e0o bi\u1ec3u m\u00f4 v\u00f5ng m\u1ea1c – t\u1eeb \u0111\u00f3 l\u00e0m ch\u1eadm ti\u1ebfn tri\u1ec3n b\u1ec7nh, gi\u1ea3m nguy c\u01a1 g\u1eb7p ph\u1ea3i bi\u1ebfn ch\u1ee9ng trong t\u01b0\u01a1ng lai \u1edf ng\u01b0\u1eddi m\u1eafc qu\u00e1ng g\u00e0.<\/p>\n<\/div>\n\n\n\n

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\u1ee8NG D\u1ee4NG T\u1ebe B\u00c0O G\u1ed0C TRONG THI\u1ebeT K\u1ebe ORGANS-ON-CHIP TRONG NGHI\u00caN C\u1ee8U SINH L\u00dd B\u1ec6NH ALZHEIMER V\u00c0 THU\u1ed0C \u0110I\u1ec0U TR\u1eca<\/strong><\/p>\n\n\n\n

Nguy\u1ec5n Ho\u00e0ng Qu\u1ef3nh Anh, \u0110inh Ho\u00e0ng Long, \u0110o\u00e0n Gia Ph\u01b0\u01a1ng Ng\u00e2n<\/p>\n\n\n\n

\u0110\u1ed9i thi:<\/strong> LAN 3.0
12KC2, tr\u01b0\u1eddng Ph\u1ed5 th\u00f4ng N\u0103ng khi\u1ebfu – \u0110\u1ea1i h\u1ecdc Qu\u1ed1c gia Th\u00e0nh ph\u1ed1 H\u1ed3 Ch\u00ed Minh<\/p>\n\n\n\n

T\u00f3m t\u1eaft (abstract):<\/strong>
T\u1ebf b\u00e0o g\u1ed1c, v\u1edbi kh\u1ea3 n\u0103ng bi\u1ec7t h\u00f3a th\u00e0nh nhi\u1ec1u lo\u1ea1i t\u1ebf b\u00e0o kh\u00e1c nhau, mang \u0111\u1ebfn m\u1ed9t con \u0111\u01b0\u1eddng \u0111\u1ea7y h\u1ee9a h\u1eb9n \u0111\u1ec3 t\u00e1i t\u1ea1o c\u00e1c c\u1ea5u tr\u00fac th\u1ea7n kinh ph\u1ee9c t\u1ea1p quan tr\u1ecdng trong vi\u1ec7c m\u00f4 ph\u1ecfng c\u00e1c t\u00ecnh tr\u1ea1ng b\u1ec7nh l\u00fd li\u00ean quan \u0111\u1ebfn B\u1ec7nh Alzheimer (AD). Nghi\u00ean c\u1ee9u n\u00e0y t\u1eadp trung v\u00e0o \u1ee9ng d\u1ee5ng t\u1ebf b\u00e0o g\u1ed1c trong vi\u1ec7c t\u1ea1o ra c\u00e1c m\u00f4 h\u00ecnh n\u00e3o tr\u00ean chip (Brain-on-Chip), \u0111\u01b0\u1ee3c thi\u1ebft k\u1ebf \u0111\u1eb7c bi\u1ec7t \u0111\u1ec3 m\u00f4 ph\u1ecfng s\u1ef1 ph\u1ee9c t\u1ea1p c\u1ee7a qu\u00e1 tr\u00ecnh ti\u1ebfn tri\u1ec3n AD. B\u1eb1ng c\u00e1ch k\u1ebft h\u1ee3p c\u00e1c t\u1ebf b\u00e0o th\u1ea7n kinh v\u00e0 t\u1ebf b\u00e0o th\u1ea7n kinh \u0111\u1ec7m c\u00f3 ngu\u1ed3n g\u1ed1c t\u1eeb t\u1ebf b\u00e0o g\u1ed1c \u0111\u00e3 \u0111\u01b0\u1ee3c \u0111i\u1ec1u ch\u1ec9nh ho\u1eb7c c\u00f3 ngu\u1ed3n g\u1ed1c t\u1eeb b\u1ec7nh nh\u00e2n v\u00e0o c\u00e1c thi\u1ebft b\u1ecb vi m\u00f4 n\u00e0y, c\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u c\u00f3 th\u1ec3 t\u00e1i t\u1ea1o c\u00e1c \u0111\u1eb7c \u0111i\u1ec3m ch\u00ednh c\u1ee7a AD, bao g\u1ed3m s\u1ef1 h\u00ecnh th\u00e0nh m\u1ea3ng b\u00e1m beta-amyloid v\u00e0 s\u1ef1 ph\u00e1t tri\u1ec3n c\u1ee7a \u0111\u00e1m r\u1ed1i s\u1ee3i th\u1ea7n kinh. Th\u00f4ng qua m\u00f4 h\u00ecnh n\u00e0y, c\u00f3 th\u1ec3 \u0111\u00e1nh gi\u00e1 m\u1ee9c \u0111\u1ed9 hi\u1ec7u qu\u1ea3 c\u1ee7a c\u00e1c lo\u1ea1i thu\u1ed1c kh\u00e1c nhau trong th\u1eddi gian th\u1ef1c, cung c\u1ea5p n\u1ec1n t\u1ea3ng n\u0103ng \u0111\u1ed9ng cho vi\u1ec7c th\u1eed nghi\u1ec7m v\u00e0 s\u00e0ng l\u1ecdc thu\u1ed1c. C\u00e1ch ti\u1ebfp c\u1eadn n\u00e0y kh\u00f4ng ch\u1ec9 \u0111\u1ea9y nhanh qu\u00e1 tr\u00ecnh kh\u00e1m ph\u00e1 thu\u1ed1c m\u00e0 c\u00f2n gi\u1ea3m thi\u1ec3u s\u1ef1 ph\u1ee5 thu\u1ed9c v\u00e0o m\u00f4 h\u00ecnh \u0111\u1ed9ng v\u1eadt, gi\u1ea3i quy\u1ebft c\u00e1c m\u1ed1i lo ng\u1ea1i v\u1ec1 \u0111\u1ea1o \u0111\u1ee9c v\u00e0 c\u1ea3i thi\u1ec7n kh\u1ea3 n\u0103ng \u0111\u00e1p \u1ee9ng thu\u1ed1c khi chuy\u1ec3n \u0111\u1ed5i t\u1eeb m\u00f4 h\u00ecnh chip l\u00ean con ng\u01b0\u1eddi (do t\u1ebf b\u00e0o \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng l\u00e0 c\u1ee7a ng\u01b0\u1eddi). S\u1ef1 k\u1ebft h\u1ee3p gi\u1eefa t\u1ebf b\u00e0o g\u1ed1c v\u00e0 h\u1ec7 th\u1ed1ng vi l\u1ecfng t\u1ea1o n\u00ean m\u00f4 h\u00ecnh AD tr\u00ean chip cung c\u1ea5p m\u1ed9t c\u00e1ch ti\u1ebfp c\u1eadn n\u0103ng \u0111\u1ed9ng, c\u00f3 th\u1ec3 m\u1edf r\u1ed9ng v\u00e0 h\u1ee3p l\u00fd v\u1ec1 m\u1eb7t \u0111\u1ea1o \u0111\u1ee9c, c\u00f3 ti\u1ec1m n\u0103ng l\u1edbn trong vi\u1ec7c l\u00e0m s\u00e1ng t\u1ecf s\u1ef1 ph\u1ee9c t\u1ea1p c\u1ee7a b\u1ec7nh l\u00fd AD v\u00e0 x\u00e1c \u0111\u1ecbnh c\u00e1c bi\u1ec7n ph\u00e1p can thi\u1ec7p \u0111i\u1ec1u tr\u1ecb m\u1edbi.<\/p>\n<\/div>\n\n\n\n

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T\u00ean \u00fd t\u01b0\u1edfng:<\/strong> Li\u1ec7u ph\u00e1p m\u1edbi trong \u0111i\u1ec1u tr\u1ecb ti\u1ec3u \u0111\u01b0\u1eddng tu\u00fdp 1: T\u1ea1o \u0111\u1ea3o tu\u1ef5 v\u1edbi l\u1edbp v\u1ecf AD-MSC ph\u1ee7 alginate t\u00edch h\u1ee3p PD-L1 gi\u00fap gi\u1ea3m t\u1ec9 l\u1ec7 lo\u1ea1i th\u1ea3i mi\u1ec5n d\u1ecbch t\u1eeb t\u1ebf b\u00e0o T<\/p>\n\n\n\n

T\u00ean \u0111\u1ed9i thi:<\/strong> Paracetamol
Tr\u01b0\u1eddng: Ph\u1ed5 th\u00f4ng N\u0103ng khi\u1ebfu, \u0110HQG-HCM<\/p>\n\n\n\n

Abstract<\/strong>
B\u1ec7nh ti\u1ec3u \u0111\u01b0\u1eddng lo\u1ea1i 1 khi\u1ebfn cho l\u01b0\u1ee3ng insulin gi\u1ea3m \u0111i, khi\u1ebfn cho kh\u1ea3 n\u0103ng ph\u00e2n gi\u1ea3i l\u01b0\u1ee3ng glucose (\u0111\u01b0\u1eddng) c\u0169ng gi\u1ea3m, l\u00e0m cho l\u01b0\u1ee3ng \u0111\u01b0\u1eddng trong m\u00e1u t\u0103ng, d\u1eabn \u0111\u1ebfn vi\u1ec7c b\u1ec7nh nh\u00e2n ph\u1ea3i s\u1eed d\u1ee5ng insulin ngo\u1ea1i sinh \u0111\u1ec3 ki\u1ec3m so\u00e1t. T\u00ecm th\u1ea5y \u0111\u01b0\u1ee3c t\u00ecm n\u0103ng trong l\u0129nh v\u1ef1c t\u1ea1o \u0111\u1ea3o tu\u1ef5 nh\u00e2n t\u1ea1o v\u1edbi vai tr\u00f2 t\u0103ng ti\u1ebft insulin v\u00e0 \u0111i\u1ec1u ho\u00e0 n\u1ed3ng \u0111\u1ed9 \u0111\u01b0\u1eddng l\u01b0u th\u00f4ng trong m\u00e1u, ch\u00fang t\u00f4i h\u01b0\u1edbng \u0111\u1ebfn \u00fd t\u01b0\u1edfng v\u1ec1 \u1ee9ng d\u1ee5ng gi\u1ea3i ph\u00e1p t\u1ea1o \u0111\u1ea3o tu\u1ef5 v\u1edbi l\u1edbp v\u1ecf AD-MSC ph\u1ee7 alginate t\u00edch h\u1ee3p PD-L1 gi\u00fap gi\u1ea3m t\u1ec9 l\u1ec7 lo\u1ea1i th\u1ea3i mi\u1ec5n d\u1ecbch t\u1eeb s\u1ef1 t\u1ea5n c\u00f4ng c\u1ee7a h\u00e0ng r\u00e0o mi\u1ec5n d\u1ecbch t\u1ebf b\u00e0o T. Vi\u1ec7c gi\u00e1p l\u1edbp \u00e1o \u1ea5y t\u1ea1o c\u01a1 h\u1ed9i cho li\u00ean k\u1ebft hydrogen gi\u1eefa ph\u1ed1i t\u1eed v\u00e0 protein PD1, gi\u00fap \u1ee9c ch\u1ebf vi\u1ec7c ti\u1ebft ra ch\u1ea5t \u0111\u1ed9c \u0111\u1ec3 th\u1ef1c hi\u1ec7n ch\u1ee9c n\u0103ng ti\u00eau di\u1ec7t c\u1ee7a t\u1ebf b\u00e0o T, t\u1eeb \u0111\u00f3 gi\u1ea3m thi\u1ec7u t\u1ec9 l\u1ec7 ch\u1ebft t\u1ebf b\u00e0o. Qua \u0111\u00f3, ch\u00fang em mu\u1ed1n h\u01b0\u1edbng \u0111\u1ebfn vi\u1ec7c t\u0103ng ch\u1ea5t l\u01b0\u1ee3ng \u0111\u1eddi s\u1ed1ng cho c\u00e1c b\u1ec7nh nh\u00e2n ti\u1ec3u \u0111\u01b0\u1eddng tu\u00fdp 1 v\u00e0 cho h\u1ecd c\u01a1 h\u1ed9i \u0111\u1ec3 c\u00f3 \u0111\u01b0\u1ee3c cu\u1ed9c s\u1ed1ng sinh ho\u1ea1t b\u00ecnh th\u01b0\u1eddng nh\u01b0 nh\u1eefng ng\u01b0\u1eddi kh\u00e1c, t\u1eadn h\u01b0\u1edfng cu\u1ed9c s\u1ed1ng, \u0111\u1eb7c bi\u1ec7t l\u00e0 kh\u00f4ng b\u1ecb g\u00e1nh n\u1eb7ng v\u1ec1 kinh t\u1ebf v\u00e0 b\u1ec7nh t\u1eadt \u0111eo b\u00e1m su\u1ed1t qu\u00e3ng \u0111\u1eddi c\u00f2n l\u1ea1i.<\/p>\n\n\n\n

Keywords:<\/strong> ti\u1ec3u \u0111\u01b0\u1eddng tu\u00fdp 1, \u0111\u1ea3o tu\u1ef5, t\u1ebf b\u00e0o g\u1ed1c \u0111a n\u0103ng c\u1ea3m \u1ee9ng (iPSC), AD-MSC, PD-L1, PD1, pFUS.<\/p>\n<\/div>\n\n\n\n

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\"\"\n\t\t\t\n\t\t\t\t\n\t\t\t<\/svg>\n\t\t<\/button><\/figure>\n\n\n\n

B\u1ea2N T\u00d3M T\u1eaeT<\/strong><\/p>\n\n\n\n

Hi\u1ec7n nay, trung b\u00ecnh c\u1ee9 2 gi\u00e2y l\u00e0 ph\u1ea3i c\u00f3 1 ca truy\u1ec1n m\u00e1u \u1edf Vi\u1ec7t Nam, v\u00e0 c\u00e1c s\u1ed1 li\u1ec7u cho th\u1ea5y \u00edt nh\u1ea5t 25% d\u00e2n s\u1ed1 ph\u1ea3i truy\u1ec1n m\u00e1u \u00edt nh\u1ea5t m\u1ed9t l\u1ea7n trong \u0111\u1eddi do c\u00e1c ch\u1ea5n th\u01b0\u01a1ng, chi\u1ebfn tranh, b\u1ec7nh di truy\u1ec1n nh\u01b0 h\u1ed3ng c\u1ea7u h\u00ecnh li\u1ec1m, ph\u1ea3i c\u1ea7n truy\u1ec1n m\u00e1u su\u1ed1t \u0111\u1eddi. Nh\u01b0ng s\u1ef1 ch\u00eanh l\u1ec7ch v\u1ec1 tr\u1eef l\u01b0\u1ee3ng m\u00e1u truy\u1ec1n (\u0111\u1eb7c bi\u1ec7t thi\u1ebfu h\u1ee5t \u1edf c\u00e1c n\u01b0\u1edbc \u0111ang ph\u00e1t tri\u1ec3n), nh\u1eefng n\u01a1i x\u1ea3y ra thi\u00ean tai, chi\u1ebfn tranh l\u00e0m vi\u1ec7c ti\u1ebfp c\u1eadn m\u00e1u hi\u1ebfn r\u1ea5t kh\u00f3 kh\u0103n. M\u1ee5c ti\u00eau c\u1ee7a nghi\u00ean c\u1ee9u l\u00e0 \u0111\u1ec3 gi\u1ea3i quy\u1ebft c\u00e1c v\u1ea5n \u0111\u1ec1 tr\u00ean, \u0111\u1ed3ng th\u1eddi gi\u1ea3i quy\u1ebft m\u1ed9t ph\u1ea7n nhu c\u1ea7u \u0111\u1eb7t l\u00ean nh\u1eefng ng\u01b0\u1eddi hi\u1ebfn m\u00e1u b\u1eb1ng vi\u1ec7c t\u1ea1o ra ngu\u1ed3n m\u00e1u nh\u00e2n t\u1ea1o t\u1eeb t\u1ebf b\u00e0o g\u1ed1c t\u1ea1o m\u00e1u (hematopoietic stem cells \u2013 HSCs). HSC \u0111\u01b0\u1ee3c l\u1ea5y t\u1eeb m\u00e1u ngo\u1ea1i vi c\u1ee7a ng\u01b0\u1eddi hi\u1ebfn theo quy tr\u00ecnh apheresis sau khi \u0111\u01b0\u1ee3c cho G-CSF v\u00e0 GM-CSF. Sau khi \u0111\u01b0\u1ee3c t\u00e1ch s\u1ebd \u0111\u01b0\u1ee3c b\u1ecf v\u00e0o t\u00fai v\u1eadn chuy\u1ec3n ch\u1ee9a IMDM c\u00f3 th\u00eam vitamin A \u0111\u1ec3 \u0111\u01b0a HSC v\u00e0o tr\u1ea1ng th\u00e1i kh\u00f4ng ho\u1ea1t \u0111\u1ed9ng \u0111\u1ec3 b\u1ea3o qu\u1ea3n. Khi \u0111\u1ebfn ph\u00f2ng th\u00ed nghi\u1ec7m th\u00ec \u0111\u1ed5 dung d\u1ecbch v\u00e0o \u0111\u1ed3 \u0111\u1ef1ng c\u00f3 \u0111\u1ed3 l\u1ecdc vitamin A \u1edf \u0111\u00e1y v\u00e0 c\u00f3 l\u1ed7 \u1edf d\u01b0\u1edbi, \u0111\u1ec3 m\u1ed9t \u0111\u1ed3 \u0111\u1ef1ng kh\u00e1c \u1edf d\u01b0\u1edbi v\u00e0 \u0111\u00f3ng k\u00edn hai \u0111\u1ed3 \u0111\u1ef1ng l\u1ea1i. T\u00e1ch hai ph\u1ea7n ra v\u00e0 \u0111\u01b0a ph\u1ea7n dung d\u1ecbch \u1edf tr\u00ean v\u00e0o \u0111\u1ed3 \u0111\u1ef1ng l\u1edbn. B\u1ecf v\u00e0o m\u00f4i tr\u01b0\u1eddng nu\u00f4i c\u1ea5y c\u00f3 th\u00eam IMDM v\u00e0 c\u00e1c d\u01b0\u1ee1ng ch\u1ea5t c\u1ea7n thi\u1ebft. B\u1ecf v\u00e0o G-CSF \u0111\u1ec3 \u0111\u01b0a HSC ra kh\u1ecfi tr\u1ea1ng th\u00e1i kh\u00f4ng ho\u1ea1t \u0111\u1ed9ng. B\u1ecf v\u00e0o chrysin v\u00e0 stem cell factor (SCF) m\u1ed9t th\u1eddi gian r\u1ed3i l\u1ecdc chrysin ra b\u1eb1ng MINM. B\u1ecf v\u00e0o epoetin alfa v\u1edbi s\u1ed1 l\u01b0\u1ee3ng nhi\u1ec1u h\u01a1n g\u1ea5p \u00edt nh\u1ea5t 3 l\u1ea7n G-CSF \u0111\u1ec3 bi\u1ec7t h\u00f3a HSC th\u00e0nh t\u1ebf b\u00e0o h\u1ed3ng c\u1ea7u. Sau khi s\u1ed1 l\u01b0\u1ee3ng \u0111\u1ea1t m\u1ee9c \u0111\u1ee7 th\u00ec l\u1ecdc theo \u0111\u00fang c\u00e1c quy tr\u00ecnh y t\u1ebf hi\u1ec7n nay. C\u00f3 nhi\u1ec1u nghi\u00ean c\u1ee9u \u0111\u00e3 t\u1ea1o ra \u0111\u01b0\u1ee3c h\u1ed3ng c\u1ea7u nh\u01b0ng s\u1ed1 l\u01b0\u1ee3ng nh\u1ecf v\u00e0 quy tr\u00ecnh k\u00e9m hi\u1ec7u qu\u1ea3. Vi\u1ec7c s\u1eed d\u1ee5ng nhi\u1ec1u ch\u1ea5t k\u1ebft h\u1ee3p: vitamin A, G-CSF, epoetin alfa, SCF, chrysin gi\u00fap k\u00edch th\u00edch HSC t\u1ea1o ra l\u01b0\u1ee3ng h\u1ed3ng c\u1ea7u l\u1edbn h\u01a1n. Ngu\u1ed3n h\u1ed3ng c\u1ea7u nh\u00e2n t\u1ea1o n\u00e0y s\u1ebd gi\u00fap nhi\u1ec1u ng\u01b0\u1eddi h\u01a1n \u0111\u01b0\u1ee3c ti\u1ebfp c\u1eadn v\u1edbi ngu\u1ed3n m\u00e1u hi\u1ebfn quan tr\u1ecdng \u0111\u1ec3 c\u1ee9u s\u1ed1ng.<\/p>\n\n\n\n

Keywords:<\/strong> HSC, t\u1ebf b\u00e0o g\u1ed1c t\u1ea1o m\u00e1u, truy\u1ec1n m\u00e1u, ch\u00eanh l\u1ec7ch tr\u1eef l\u01b0\u1ee3ng, G-CSF, GM-CSF, IMDM, epoetin alfa, MINM, stem cell factor, chrysin, vitamin A, chi\u1ebfn tranh<\/p>\n<\/div>\n\n\n\n

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\"\"\n\t\t\t\n\t\t\t\t\n\t\t\t<\/svg>\n\t\t<\/button><\/figure>\n\n\n\n

\u1ee8NG D\u1ee4NG C\u1ee6A CHITOSAN TRONG \u0110I\u1ec0U TR\u1eca V\u1ebeT TH\u01af\u01a0NG H\u1ede NGO\u00c0I DA \u0110\u01af\u1ee2C CHI\u1ebeT T\u00c1CH T\u1eea T\u1ebe B\u00c0O G\u1ed0C<\/strong><\/p>\n\n\n\n

S\u00d3I C\u00d4 \u0110\u1ed8C<\/strong><\/p>\n\n\n\n

Trong cu\u1ed9c s\u1ed1ng, nh\u1eefng v\u1ebft th\u01b0\u01a1ng ngo\u00e0i da l\u00e0 kh\u00f4ng th\u1ec3 tr\u00e1nh kh\u1ecfi, nh\u01b0 v\u1ebft x\u01b0\u1edbc, v\u1ebft b\u1ecfng, v\u1ebft lo\u00e9t,\u2026 V\u00ec th\u1ebf, chitosan \u0111\u01b0\u1ee3c tr\u00edch xu\u1ea5t t\u1eeb chitin \u1edf v\u1ecf t\u00f4m c\u00f3 th\u1ec3 h\u1ed7 tr\u1ee3 vi\u1ec7c l\u00e0nh v\u1ebft th\u01b0\u01a1ng nhanh ch\u00f3ng, hi\u1ec7u qu\u1ea3 v\u00e0 mang t\u00ednh th\u1ea9m m\u1ef9 h\u01a1n. Trong nghi\u00ean c\u1ee9u n\u00e0y, t\u1ebf b\u00e0o g\u1ed1c ph\u00f4i t\u00f4m \u0111\u01b0\u1ee3c ph\u00e2n l\u1eadp v\u00e0 nu\u00f4i c\u1ea5y th\u00e0nh t\u1ebf b\u00e0o bi\u1ec3u m\u00f4 t\u00f4m, t\u1eeb \u0111\u00f3 h\u00ecnh th\u00e0nh \u0111\u01b0\u1ee3c v\u1ecf t\u00f4m trong ph\u00f2ng th\u00ed nghi\u1ec7m. Sau \u0111\u00f3, c\u00e1c ph\u01b0\u01a1ng ph\u00e1p sinh h\u1ecdc th\u00e2n thi\u1ec7n v\u1edbi m\u00f4i tr\u01b0\u1eddng \u0111\u01b0\u1ee3c th\u1ef1c hi\u1ec7n \u0111\u1ec3 chi\u1ebft xu\u1ea5t \u0111\u01b0\u1ee3c chitosan t\u1eeb chitin trong v\u1ecf t\u00f4m. M\u1ee5c ti\u00eau c\u1ee7a nghi\u00ean c\u1ee9u l\u00e0 khi\u1ebfn vi\u1ec7c nu\u00f4i c\u1ea5y v\u1ecf t\u00f4m trong ph\u00f2ng th\u00ed nghi\u1ec7m v\u1eeba c\u00f3 ch\u1ea5t l\u01b0\u1ee3ng t\u1ed1t h\u01a1n, v\u1eeba mang l\u1ee3i \u00edch kinh t\u1ebf h\u01a1n so v\u1edbi v\u1ecf t\u00f4m \u0111\u01b0\u1ee3c thu t\u1eeb ch\u1ea5t th\u1ea3i h\u1eefu c\u01a1, m\u00e0 l\u1ea1i v\u1eeba c\u00f3 gi\u00e1 th\u00e0nh th\u1ea5p \u0111\u1ec3 ti\u1ebfp c\u1eadn \u0111\u01b0\u1ee3c v\u1edbi m\u1ecdi \u0111\u1ed1i t\u01b0\u1ee3ng c\u0169ng nh\u01b0 thu\u1ed1c ch\u1ee9a chitosan kh\u00f4ng nh\u1eefng l\u00e0nh t\u00ednh, hi\u1ec7u qu\u1ea3, gi\u00e1 c\u1ea3 ph\u1ea3i ch\u0103ng m\u00e0 \u0111\u1eb7c bi\u1ec7t c\u00f2n c\u1ea3i thi\u1ec7n \u0111\u01b0\u1ee3c t\u00ecnh tr\u1ea1ng v\u1ebft th\u01b0\u01a1ng l\u00e2u l\u00e0nh h\u01a1n b\u00ecnh th\u01b0\u1eddng c\u1ee7a ng\u01b0\u1eddi b\u1ea1i li\u1ec7t v\u00e0 ti\u1ec3u \u0111\u01b0\u1eddng. \u0110\u1ed1i t\u01b0\u1ee3ng ch\u00ednh m\u00e0 ch\u00fang em nh\u1eafm \u0111\u1ebfn trong nghi\u00ean c\u1ee9u n\u00e0y ng\u01b0\u1eddi b\u1ecb ti\u1ec3u \u0111\u01b0\u1eddng v\u00e0 ng\u01b0\u1eddi b\u1ecb b\u1ea1i li\u1ec7t do kh\u1ea3 n\u0103ng h\u1ed3i ph\u1ee5c v\u1ebft th\u01b0\u01a1ng c\u1ee7a h\u1ecd ch\u1eadm h\u01a1n so v\u1edbi ng\u01b0\u1eddi c\u00f3 th\u1ec3 ch\u1ea5t b\u00ecnh th\u01b0\u1eddng. \u0110i\u1ec1u n\u00e0y s\u1ebd gi\u00fap h\u1ecd ph\u1ee5c h\u1ed3i v\u1ebft th\u01b0\u01a1ng nhanh h\u01a1n v\u00e0 kh\u00f4ng g\u00e2y c\u1ea3m gi\u00e1c kh\u00f3 ch\u1ecbu. T\u1eeb \u0111\u00f3, c\u00f3 th\u1ec3 c\u1ea3i thi\u1ec7n \u0111\u01b0\u1ee3c \u0111\u1eddi s\u1ed1ng sinh ho\u1ea1t m\u1ed9t c\u00e1ch t\u1ed1t h\u01a1n.<\/p>\n<\/div>\n\n\n\n

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\"\"\n\t\t\t\n\t\t\t\t\n\t\t\t<\/svg>\n\t\t<\/button><\/figure>\n\n\n\n

\u0110\u1ed8I THI:<\/strong> STEM CELL NNT<\/p>\n\n\n\n

\u00dd T\u01af\u1edeNG:<\/strong> “BI\u1ec6T H\u00d3A T\u1ebe B\u00c0O G\u1ed0C TRUNG M\u00d4 C\u00d3 NGU\u1ed2N G\u1ed0C T\u1eea T\u1ebe B\u00c0O M\u00d4 D\u00c2Y R\u1ed0N TH\u00c0NH T\u1ebe B\u00c0O \u03b2 \u1ee8NG D\u1ee4NG TRONG \u0110I\u1ec0U TR\u1eca B\u1ec6NH TI\u1ec2U \u0110\u01af\u1edcNG TYPE 1 TR\u00caN M\u00d4 H\u00ccNH CHU\u1ed8T”<\/p>\n\n\n\n

GI\u1edaI THI\u1ec6U<\/strong>
Hi\u1ec7n nay, c\u00e1c ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng type 1 (T1DM) c\u00f2n h\u1ea1n ch\u1ebf, b\u1ec7nh nh\u00e2n m\u1eafc T1DM ph\u1ea3i d\u1ef1a v\u00e0o vi\u1ec7c ti\u00eam insulin ngo\u1ea1i sinh trong su\u1ed1t qu\u00e3ng \u0111\u1eddi c\u00f2n l\u1ea1i \u0111\u1ec3 duy tr\u00ec ki\u1ec3m so\u00e1t \u0111\u01b0\u1eddng huy\u1ebft.<\/p>\n\n\n\n

M\u1ee4C TI\u00caU<\/strong>
\u00dd t\u01b0\u1edfng nh\u1eb1m h\u01b0\u1edbng \u0111\u1ebfn vi\u1ec7c t\u1ed1i \u01b0u h\u00f3a ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb gi\u00fap \u0111em l\u1ea1i hi\u1ec7u qu\u1ea3 l\u00e2u d\u00e0i t\u1eeb \u0111\u00f3 c\u00f3 th\u1ec3 \u1ee9ng d\u1ee5ng tr\u00ean ng\u01b0\u1eddi.<\/p>\n\n\n\n

PH\u01af\u01a0NG PH\u00c1P<\/strong><\/p>\n\n\n\n

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B\u01b0\u1edbc 1: Thu nh\u1eadn m\u1eabu m\u00f4 d\u00e2y r\u1ed1n.<\/p>\n\n\n\n

B\u01b0\u1edbc 2: Ph\u00e2n l\u1eadp, nu\u00f4i c\u1ea5y t\u1ebf b\u00e0o g\u1ed1c \u1ee9ng vi\u00ean t\u1eeb m\u1eabu m\u00f4 d\u00e2y r\u1ed1n.<\/p>\n\n\n\n

B\u01b0\u1edbc 3: \u0110\u1ecbnh danh t\u1ebf b\u00e0o g\u1ed1c \u1ee9ng vi\u00ean \u0111\u01b0\u1ee3c ph\u00e2n l\u1eadp t\u1eeb m\u00f4 d\u00e2y r\u1ed1n.<\/p>\n\n\n\n

B\u01b0\u1edbc 4: Ph\u00e2n l\u1eadp v\u00e0 nu\u00f4i c\u1ea5y t\u1ebf b\u00e0o \u0111\u1ea3o t\u1ee5y c\u1ee7a chu\u1ed9t.<\/p>\n\n\n\n

B\u01b0\u1edbc 5: \u0110\u1ed3ng nu\u00f4i c\u1ea5y t\u1ebf b\u00e0o g\u1ed1c trung m\u00f4, t\u1ebf b\u00e0o \u0111\u1ea3o t\u1ee5y c\u1ee7a chu\u1ed9t \u0111\u1ec3 t\u1ea1o th\u00e0nh t\u1ebf b\u00e0o \u03b2 c\u00f3 kh\u1ea3 n\u0103ng ti\u1ebft insulin.<\/p>\n\n\n\n

B\u01b0\u1edbc 6: Ki\u1ec3m tra l\u01b0\u1ee3ng insulin ti\u1ebft ra.<\/p>\n\n\n\n

B\u01b0\u1edbc 7: \u0110\u00e1nh gi\u00e1 t\u00ednh an to\u00e0n c\u1ee7a c\u00e1c t\u1ebf b\u00e0o\/c\u1ee5m t\u1ebf b\u00e0o \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 gh\u00e9p v\u00e0o chu\u1ed9t.<\/p>\n\n\n\n

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  • \u0110\u00e1nh gi\u00e1 s\u1ef1 to\u00e0n v\u1eb9n nhi\u1ec5m s\u1eafc th\u1ec3<\/li>\n\n\n\n
  • Kh\u1ea3 n\u0103ng g\u00e2y ung th\u01b0<\/li>\n\n\n\n
  • Ki\u1ec3m tra m\u1ee9c bi\u1ec3u hi\u1ec7n c\u1ee7a c\u00e1c gen sinh u v\u00e0 c\u00e1c gen \u1ee9c ch\u1ebf kh\u1ed1i u \u1edf m\u1ee9c phi\u00ean m\u00e3<\/li>\n\n\n\n
  • \u0110\u00e1nh gi\u00e1 t\u00ednh sinh u in vivo<\/li>\n\n\n\n
  • Kh\u1ea3 n\u0103ng t\u1ea1o u tr\u00ean m\u00f4 h\u00ecnh chu\u1ed9t<\/li>\n\n\n\n
  • Kh\u1ea3 n\u0103ng g\u00e2y ch\u1ebft<\/li>\n<\/ul>\n\n\n\n

    B\u01b0\u1edbc 8:<\/strong> C\u1ea5y c\u00e1c \u0111\u1ea3o t\u1ee5y v\u00e0 t\u1ebf b\u00e0o g\u1ed1c trung m\u00f4 d\u01b0\u1edbi nang th\u1eadn \u1edf chu\u1ed9t nh\u1eadn, ki\u1ec3m tra n\u1ed3ng \u0111\u1ed9 glucose.<\/p>\n<\/div>\n<\/div>\n\n\n\n

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    \"\"\n\t\t\t\n\t\t\t\t\n\t\t\t<\/svg>\n\t\t<\/button><\/figure>\n\n\n\n

    \u0110\u1ed8I THI:<\/strong> WE BARE BEARS<\/p>\n\n\n\n

    \u00dd T\u01af\u1edeNG:<\/strong> \u1ee8NG D\u1ee4NG H\u1ec6 TH\u1ed0NG \u0110\u1ed2NG NU\u00d4I C\u1ea4Y GI\u1eeeA T\u1ebe B\u00c0O NHU M\u00d4 C\u1ee6A GAN V\u00c0 T\u1ebe B\u00c0O BI\u1ec2U M\u00d4 \u1ed0NG M\u1eacT TRONG S\u1ea2N XU\u1ea4T M\u1eacT G\u1ea4U<\/p>\n\n\n\n

    ABSTRACT:<\/strong>
    V\u00ec nh\u1eefng l\u1ee3i \u00edch to l\u1edbn c\u1ee7a m\u1eadt g\u1ea5u trong y h\u1ecdc, vi\u1ec7c khai th\u00e1c m\u1eadt g\u1ea5u \u0111ang ng\u00e0y c\u00e0ng tr\u1edf n\u00ean ph\u1ed5 bi\u1ebfn, tuy nhi\u00ean, quy tr\u00ecnh thu nh\u1eadn m\u1eadt g\u1ea5u truy\u1ec1n th\u1ed1ng l\u1ea1i c\u1ef1c k\u1ef3 t\u00e0n nh\u1eabn v\u00e0 l\u00e0m \u1ea3nh h\u01b0\u1edfng n\u1eb7ng n\u1ec1 \u0111\u1ebfn c\u00e1c qu\u1ea7n th\u1ec3 g\u1ea5u trong t\u1ef1 nhi\u00ean. Ch\u01b0a d\u1eebng l\u1ea1i \u1edf \u0111\u00f3, ch\u1ea5t l\u01b0\u1ee3ng c\u1ee7a m\u1eadt g\u1ea5u \u0111\u01b0\u1ee3c thu nh\u1eadn theo ph\u01b0\u01a1ng ph\u00e1p truy\u1ec1n th\u1ed1ng th\u01b0\u1eddng kh\u00f4ng \u0111\u01b0\u1ee3c \u0111\u1ea3m b\u1ea3o v\u00e0 c\u00f3 kh\u1ea3 n\u0103ng g\u00e2y ra c\u00e1c v\u1ea5n \u0111\u1ec1 v\u1ec1 s\u1ee9c kh\u1ecfe cho ng\u01b0\u1eddi s\u1eed d\u1ee5ng. Do \u0111\u00f3, gi\u1ea3i ph\u00e1p ti\u1ec1m n\u0103ng \u0111\u01b0\u1ee3c nh\u00f3m \u0111\u1ec1 xu\u1ea5t nh\u1eb1m gi\u1ea3i quy\u1ebft nh\u1eefng v\u1ea5n \u0111\u1ec1 nan gi\u1ea3i n\u00eau tr\u00ean l\u00e0 t\u00ecm ra m\u1ed9t ngu\u1ed3n s\u1ea3n xu\u1ea5t m\u1eadt g\u1ea5u ph\u00f9 h\u1ee3p v\u1edbi c\u00e1c chu\u1ea9n m\u1ef1c \u0111\u1ea1o \u0111\u1ee9c v\u00e0 x\u00e3 h\u1ed9i. Nh\u00f3m ch\u00fang em \u0111\u00e3 ti\u1ebfn h\u00e0nh x\u00e2y d\u1ef1ng quy tr\u00ecnh thu nh\u1eadn m\u1eadt g\u1ea5u nh\u00e2n t\u1ea1o b\u1eb1ng ph\u01b0\u01a1ng ph\u00e1p \u0111\u1ed3ng nu\u00f4i c\u1ea5y t\u1ebf b\u00e0o nhu m\u00f4 gan v\u00e0 t\u1ebf b\u00e0o bi\u1ec3u m\u00f4 \u1ed1ng m\u1eadt. T\u1ebf b\u00e0o g\u1ed1c trung m\u00f4 \u0111\u01b0\u1ee3c ph\u00e2n l\u1eadp t\u1eeb m\u00f4 m\u1ee1 c\u1ee7a g\u1ea5u n\u00e2u (danh ph\u00e1p khoa h\u1ecdc: Ursus arctos), sau \u0111\u00f3 \u0111\u01b0\u1ee3c bi\u1ec7t h\u00f3a th\u00e0nh t\u1ebf b\u00e0o nhu m\u00f4 gan v\u00e0 t\u1ebf b\u00e0o bi\u1ec3u m\u00f4 \u1ed1ng m\u1eadt. Hai d\u00f2ng t\u1ebf b\u00e0o k\u1ec3 tr\u00ean \u0111\u01b0\u1ee3c nu\u00f4i c\u1ea5y b\u1eb1ng h\u1ec7 th\u1ed1ng \u0111\u1ed3ng nu\u00f4i c\u1ea5y, qua \u0111\u00f3 cho ph\u00e9p ch\u00fang t\u01b0\u01a1ng t\u00e1c v\u00e0 \u201cgiao ti\u1ebfp\u201d v\u1edbi nhau, \u0111\u1ed3ng th\u1eddi m\u00f4 ph\u1ecfng \u0111i\u1ec1u ki\u1ec7n sinh l\u00fd c\u1ee7a \u1ed1ng m\u1eadt v\u00e0 t\u1ea1o \u0111i\u1ec1u ki\u1ec7n \u0111\u1ec3 c\u00e1c organoid t\u1ed5ng h\u1ee3p acid m\u1eadt c\u00f3 ho\u1ea1t t\u00ednh sinh h\u1ecdc. Sau khi thu nh\u1eadn d\u1ecbch ti\u1ebft, th\u00e0nh ph\u1ea7n h\u00f3a h\u1ecdc c\u1ee7a d\u1ecbch ti\u1ebft s\u1ebd \u0111\u01b0\u1ee3c ph\u00e2n t\u00edch b\u1eb1ng m\u1ed9t s\u1ed1 k\u1ef9 thu\u1eadt chuy\u00ean bi\u1ec7t. B\u1eb1ng ph\u01b0\u01a1ng ph\u00e1p n\u00e0y, nh\u00f3m ch\u00fang em hy v\u1ecdng c\u00f3 th\u1ec3 s\u1ea3n xu\u1ea5t m\u1eadt g\u1ea5u v\u1edbi s\u1ed1 l\u01b0\u1ee3ng v\u00e0 ch\u1ea5t l\u01b0\u1ee3ng cao h\u01a1n so v\u1edbi quy tr\u00ecnh khai th\u00e1c m\u1eadt g\u1ea5u t\u1ef1 nhi\u00ean.<\/p>\n<\/div>\n\n\n\n

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    \"\"\n\t\t\t\n\t\t\t\t\n\t\t\t<\/svg>\n\t\t<\/button><\/figure>\n\n\n\n

    Title:<\/strong> Innovative Combined Therapy for Type 1 Diabetes: Stem Cell-Derived Islet Differentiation, Mesenchymal Stem Cells, and Protective Encapsulation<\/p>\n\n\n\n

    WE BARE GIRLS<\/strong> – International University, VNUHCM<\/p>\n\n\n\n

    \n

    Abstract<\/strong><\/p>\n\n\n\n

    Type 1 diabetes presents a significant health challenge characterized by immune-mediated destruction of pancreatic beta cells, resulting in insulin deficiency and glucose dysregulation. Existing treatments, relying primarily on exogenous insulin, fail to address the immune-driven beta cell damage, leading to unstable glycemic control and long-term complications. This idea introduces an innovative therapeutic approach aiming to revolutionize Type 1 diabetes management. The proposed strategy integrates stem cell-based islet differentiation, incorporating mesenchymal stem cells (MSCs), and a critical encapsulation system. The encapsulation system serves as a protective shield for transplanted cells, safeguarding them from immune attack and potentially prolonging their functionality within the host environment.<\/p>\n\n\n\n

    Stem cell-based islet differentiation offers a renewable source of insulin-producing cells, addressing the insulin deficit characteristic of Type 1 diabetes. However, these transplanted cells face the challenge of immune rejection, hindering their long-term efficacy. Herein lies the significance of the encapsulation system, which aims to create a physical barrier around the transplanted cells while allowing the exchange of essential nutrients and insulin.<\/p>\n\n\n\n

    Moreover, the inclusion of MSCs complements this approach by leveraging their immunomodulatory properties. MSCs not only potentially regulate the immune response against transplanted cells but also create a conducive microenvironment, supporting the survival and functionality of the transplanted cells within the encapsulation.<\/p>\n\n\n\n

    This comprehensive therapeutic approach aims to address multiple facets of Type 1 diabetes management: replenishing insulin-producing cells, protecting them from immune attack, and fostering a conducive environment for their long-term functionality. The proposed therapy holds promise in significantly improving treatment outcomes, potentially offering more sustainable and effective solutions for individuals living with Type 1 diabetes.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

    T\u00ean \u0111\u1ed9i thi: 3 Con nh\u00e1i T\u00ean \u00fd t\u01b0\u1edfng: Lactose intolerance treatment via genetically engineered bacteria. Gi\u1edbi thi\u1ec7u: Lactose intolerance has a high prevalence worldwide, ranging between 57% and 65%. It is caused by a reduction or loss of the activity of the intestinal enzyme lactase\u2212phlorizin hydrolase, responsible for the digestion of lactose. This alteration […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"custom-with-title","meta":{"footnotes":""},"class_list":["post-439","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/stemcellinnovation.com.vn\/2023\/wp-json\/wp\/v2\/pages\/439","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/stemcellinnovation.com.vn\/2023\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/stemcellinnovation.com.vn\/2023\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/stemcellinnovation.com.vn\/2023\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/stemcellinnovation.com.vn\/2023\/wp-json\/wp\/v2\/comments?post=439"}],"version-history":[{"count":6,"href":"https:\/\/stemcellinnovation.com.vn\/2023\/wp-json\/wp\/v2\/pages\/439\/revisions"}],"predecessor-version":[{"id":595,"href":"https:\/\/stemcellinnovation.com.vn\/2023\/wp-json\/wp\/v2\/pages\/439\/revisions\/595"}],"wp:attachment":[{"href":"https:\/\/stemcellinnovation.com.vn\/2023\/wp-json\/wp\/v2\/media?parent=439"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}